Antibody Classes and Characteristics Worksheet
Practice matching, fill in the blanks, True or False, and recall for the 5 immunoglobulin classes (IgG, IgM, IgA, IgE, IgD) with instant feedback.
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Part A
Match It! 🧩
Click a class on the left, then click its matching feature on the right.
Antibody Class
Feature
Part B
Fill in the Blanks! ✏️
1
The two types of light chains are and lambda.
2
Enzyme cleaves IgG into two Fab and one Fc.
3
Enzyme cleaves IgG into a single F(ab’)2.
4
The region provides flexibility.
5
Hypervariable regions are called .
6
is first produced in primary response.
7
is predominant in secondary response.
8
Pentameric IgM is held together by the .
9
In secretory IgA, the protects the molecule.
10
The region is responsible for specificity.
Part C
True or False? 🤔
1. IgG is the first antibody produced in a primary response.
2. IgM is the most efficient class at activating classical complement.
3. All IgG subclasses cross the placenta equally well.
4. An antibody can have both kappa and lambda chains simultaneously.
5. IgE is the most heat-labile of all immunoglobulins.
6. IgA activates complement through the classical pathway.
7. IgM is a pentamer in serum but a monomer on B cells.
8. IgG3 is the subclass with the highest serum concentration.
9. Idiotypes refer to variations within the same species.
10. Measuring IgM is useful for diagnosing an acute infection.
Part D
From Memory! 🌟
Crosses the placenta
✅ IgG
Mediates Type I Allergy
✅ IgE
Waldenström macroglobulinemia
✅ IgM
Found in colostrum
✅ IgA
Surface of unstimulated B cells
✅ IgD
Parasitic worm infections
✅ IgE
Most abundant in serum
✅ IgG
First in primary response
✅ IgM
Patrols mucosal surfaces
✅ IgA
Fetal Anti-D antibody
✅ IgG
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